Author: Jordana-Lluch, Elena; Giménez, Montserrat; Quesada, M. Dolores; Ausina, Vicente; Martró, Elisa
Title: Improving the Diagnosis of Bloodstream Infections: PCR Coupled with Mass Spectrometry Document date: 2014_4_9
ID: 05zahl5n_27
Snippet: Although these sensitivity values are not directly comparable because they were calculated in different ways, the Laffler et al. study had a higher detection rate of the PCR/ESI-MS on whole blood specimens with a paired positive blood culture. As many factors may affect the sensitivity of molecular methods, a direct comparison between studies is difficult. Differences in the clinical condition of the patients, their characteristics (e.g., age, an.....
Document: Although these sensitivity values are not directly comparable because they were calculated in different ways, the Laffler et al. study had a higher detection rate of the PCR/ESI-MS on whole blood specimens with a paired positive blood culture. As many factors may affect the sensitivity of molecular methods, a direct comparison between studies is difficult. Differences in the clinical condition of the patients, their characteristics (e.g., age, antimicrobial treatment at the time of the blood draw), the microorganisms isolated, the number of blood cultures taken, and the volume of blood drawn for culture may result in differences between studies [36] .
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