Selected article for: "complement component and MBL bind"
Author: Aran Singanayagam; Su-Ling Loo; Maria Calderazzo; Lydia J Finney; Maria-Belen Trujillo Torralbo; Eteri Bakhsoliani; Jason Girkin; Punnam Veerati; Prabuddha S Pathinayake; Kristy S Nichol; Andrew Reid; Joseph Foottit; Sebastian L Johnston; Nathan W Bartlett; Patrick Mallia
Title: Anti-microbial immunity is impaired in COPD patients with frequent exacerbations
  • Document date: 2019_5_9
    • ID: 72jzqm86_51
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/632372 doi: bioRxiv preprint exacerbators at stable state and during virus positive exacerbation. The potential importance of MBL-2 during virus-associated exacerbation was further demonstrated by our finding that its expression correlated negatively with bacterial loads during exacerbation. MBL is a key component of innate immunity that activate.....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/632372 doi: bioRxiv preprint exacerbators at stable state and during virus positive exacerbation. The potential importance of MBL-2 during virus-associated exacerbation was further demonstrated by our finding that its expression correlated negatively with bacterial loads during exacerbation. MBL is a key component of innate immunity that activates the lectin complement pathway and is involved in the process of bacterial phagocytosis 31 . MBL deficiency is associated with susceptibility to respiratory tract infections and pneumonia in healthy individuals 32, 33 and to increased risk of sepsis in animal models 34 . MBL can bind to various pathogens of relevance to COPD exacerbations including both viruses and bacteria 35 .

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