Author: Wang, Xiaoli; Wang, Jiao; Zhang, Wenmei; Li, Boye; Zhu, Ying; Hu, Qin; Yang, Yishu; Zhang, Xiaoguang; Yan, Hong; Zeng, Yi
Title: Inhibition of Human Immunodeficiency Virus Type 1 Entry by a Keggin Polyoxometalate Document date: 2018_5_16
ID: 1ghbutov_43
Snippet: The antiviral activity of POMs was first documented in 1970s, and they were later extensively studied in influenza, polioviruses, herpes simplex virus, etc. [13] [14] [15] . Especially, most POMs were found effective against HIV-1, HIV-2 and simian immunodeficiency virus (SIV) [21, 35] . HPA-23, known as antimonium tungstate, was one of the first-generation POM and the only one of all studied (A) Protease activity was assessed using a commercial .....
Document: The antiviral activity of POMs was first documented in 1970s, and they were later extensively studied in influenza, polioviruses, herpes simplex virus, etc. [13] [14] [15] . Especially, most POMs were found effective against HIV-1, HIV-2 and simian immunodeficiency virus (SIV) [21, 35] . HPA-23, known as antimonium tungstate, was one of the first-generation POM and the only one of all studied (A) Protease activity was assessed using a commercial kit, and pepstatin A was used as a positive control; (B) Reverse transcriptase activity was analyzed using a commercial kit with colorimetric assays; the percent inhibition was calculated as compared with the reverse transcriptase control. Nevirapine (NVP, 5 µM) was included as a positive control; (C) Integrase 3 -processing activity was analyzed by fluorescence resonance energy transfer. RAL was used as a positive control. All data were means ± standard deviations (SD) and were representative of three independent experiments.
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