Author: Pattyn, Els; Verhee, Annick; Uyttendaele, Isabel; Piessevaux, Julie; Timmerman, Evy; Gevaert, Kris; Vandekerckhove, Joël; Peelman, Frank; Tavernier, Jan
Title: HyperISGylation of Old World Monkey ISG15 in Human Cells Document date: 2008_6_18
ID: 1eksm537_1
Snippet: Type I Interferons (IFN)s are involved in host defense mechanisms, particularly against viral infections. They induce a so-called ''antiviral state'' by inducing both cytosolic and nuclear events. IFN Stimulated Gene 15 (ISG15) is an Ubiquitin (Ub)-Like molecule (UbL), highly induced upon both type I and type II IFN treatment [1] . It is expressed as a 17 kDa protein, containing 2 Ub domains and a C-terminal oligopeptide (eg. octapeptide in human.....
Document: Type I Interferons (IFN)s are involved in host defense mechanisms, particularly against viral infections. They induce a so-called ''antiviral state'' by inducing both cytosolic and nuclear events. IFN Stimulated Gene 15 (ISG15) is an Ubiquitin (Ub)-Like molecule (UbL), highly induced upon both type I and type II IFN treatment [1] . It is expressed as a 17 kDa protein, containing 2 Ub domains and a C-terminal oligopeptide (eg. octapeptide in human, hexapeptide in mice). Maturation of ISG15 includes N-terminal Met excision [2] and removal of the C-terminal peptide giving a 15 kDa protein [3] . Maturated ISG15 can then be conjugated via an isopeptide binding to the e-amino group of a Lys residue in the target protein [4] . Alternatively, the processed 15 kDa ISG15 molecule can be secreted and exerts immunoregulatory functions on peripheral blood lymphocytes [5] .
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