Author: Quan-xin Long; Hai-jun Deng; Juan Chen; Jieli Hu; Bei-zhong Liu; Pu Liao; Yong Lin; Li-hua Yu; Zhan Mo; Yin-yin Xu; Fang Gong; Gui-cheng Wu; Xian-xiang Zhang; Yao-kai Chen; Zhi-jie Li; Kun Wang; Xiao-li Zhang; Wen-guang Tian; Chang-chun Niu; Qing-jun Yang; Jiang-lin Xiang; Hong-xin Du; Hua-wen Liu; Chunhui Lang; Xiao-he Luo; Shao-bo Wu; Xiao-ping Cui; Zheng Zhou; Jing Wang; Cheng-jun Xue; Xiao-feng Li; Li Wang; Xiao-jun Tang; Yong Zhang; Jing-fu Qiu; Xia-mao Liu; Jin-jing Li; De-chun Zhang; Fan Zhang; Xue-fei Cai; Deqiang Wang; Yuan Hu; Ji-hua Ren; Ni Tang; Ping Liu; Qin Li; Ai-long Huang
Title: Antibody responses to SARS-CoV-2 in COVID-19 patients: the perspective application of serological tests in clinical practice Document date: 2020_3_20
ID: dm8yl4xu_32
Snippet: is the (which was not peer-reviewed) The copyright holder for this preprint . https: //doi.org/10.1101 //doi.org/10. /2020 positive IgG (3/4) or IgM (3/4) in their first samples (Fig. 4) . Patients 3 showed an over 4-fold increase in IgG at the latter time point. Interestingly, RT-PCR test of patient 3's sample became positive one day between the two sampling, confirming the infection of SARS-CoV-2. An increase in the titer of IgM was observed in.....
Document: is the (which was not peer-reviewed) The copyright holder for this preprint . https: //doi.org/10.1101 //doi.org/10. /2020 positive IgG (3/4) or IgM (3/4) in their first samples (Fig. 4) . Patients 3 showed an over 4-fold increase in IgG at the latter time point. Interestingly, RT-PCR test of patient 3's sample became positive one day between the two sampling, confirming the infection of SARS-CoV-2. An increase in the titer of IgM was observed in the 3 sequential samples from patient 1 (< 2-folds). Patient 2 was positive in both the IgG and IgM. Patient 4 had high IgG and IgM titers, more than 100-fold and 10-fold higher respectively, than the cut-off values at both time points. Although the latter 3 patients did not show a seroconversion or a > 4-fold change of IgG titers between sequential samples, we still support a COVID-19 diagnosis for them.
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