Inhibition of Human Cytomegalovirus Entry into Host Cells through A Pleiotropic Small Molecule

Elste, James; Kaltenbach, Dominik; Patel, Vraj R.; Nguyen, Max T.; Sharthiya, Harsh; Tandon, Ritesh; Mehta, Satish K.; Volin, Michael V.; Fornaro, Michele; Tiwari, Vaibhav; Desai, Umesh R.

Effect of SPGG on HFF-1 and SK-N-MC cells. The cells monolayers were incubated in the presence or absence of SPGG in a dose dependent manner. Controls; (+) represents maximum lactate dehydrogenase (LDH) activity control, (−) represents the spontaneous LDH release control. A oneway analysis of variance (ANOVA) determined significant difference among means with a P-value of < 0.0001 in both cell types. Dunnett's multiple comparison test found significant differences between the mean of each treatment in comparison to the mean of the positive control column, (****) signifies a P-value of < 0.0001. The graph is indicative of the mean values and SD of triplicate experiment.