Author: Elste, James; Kaltenbach, Dominik; Patel, Vraj R.; Nguyen, Max T.; Sharthiya, Harsh; Tandon, Ritesh; Mehta, Satish K.; Volin, Michael V.; Fornaro, Michele; Tiwari, Vaibhav; Desai, Umesh R.
Title: Inhibition of Human Cytomegalovirus Entry into Host Cells through A Pleiotropic Small Molecule Document date: 2020_2_29
ID: 031ro01b_4
Snippet: One group of receptors that could be targeted by such agents include the heparan sulfate proteoglycans. First, HCMV glycoproteins, especially gB, are known to bind to HS chains present on these cell surface proteoglycans [41] . Thus, appropriate competitive molecules would be expected to reduce cellular attachment and entry. Second, many host cell surface receptors are also known to bind to HS such as growth factor receptors (e.g., PDGF-R and EGF.....
Document: One group of receptors that could be targeted by such agents include the heparan sulfate proteoglycans. First, HCMV glycoproteins, especially gB, are known to bind to HS chains present on these cell surface proteoglycans [41] . Thus, appropriate competitive molecules would be expected to reduce cellular attachment and entry. Second, many host cell surface receptors are also known to bind to HS such as growth factor receptors (e.g., PDGF-R and EGF-R) and neuropilin [28] , which could offer additional opportunities for competitive inhibition. Third, inhibitors of viral entry could be expected to have downstream consequences such as the expression of viral immediate-early genes, whose products play a key role in the pathogenesis of HCMV infection, and prevention or reduction in host immunomodulation [42] .
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