Author: Leclercq, Loïc
Title: Interactions between cyclodextrins and cellular components: Towards greener medical applications? Document date: 2016_12_7
ID: 16pzlvzz_17
Snippet: The first well-documented effect of CDs is probably hemolysis which corresponds to the lysis of red blood cells (erythrocytes) and the release of their contents into surrounding fluid (blood plasma). In 1982, Irie and co-workers reported that native CDs are able to cause hemolysis of human erythrocytes [59] . This behavior occurs at relatively high concentrations (>1 mM) and that the degree of cholesterol extraction is a function of the CD used, .....
Document: The first well-documented effect of CDs is probably hemolysis which corresponds to the lysis of red blood cells (erythrocytes) and the release of their contents into surrounding fluid (blood plasma). In 1982, Irie and co-workers reported that native CDs are able to cause hemolysis of human erythrocytes [59] . This behavior occurs at relatively high concentrations (>1 mM) and that the degree of cholesterol extraction is a function of the CD used, its concentration, incubation time, temperature. For instance, in given conditions (isotonic solution with similar incubation time and temperature), the observed hemolysis is in the order γ-CD < α-CD < β-CD.
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