Author: Leclercq, Loïc
Title: Interactions between cyclodextrins and cellular components: Towards greener medical applications? Document date: 2016_12_7
ID: 16pzlvzz_33
Snippet: As native and modified CDs are able to complex some amino acids which constitute peptides and proteins, these molecules can be useful for their separation by capillary zone electrophoresis. In this context, Rathore and Horváth reported that carboxymethyl-β-CD (CM-β-CD) in the electrophoretic medium (aqueous buffer solution, pH 2.5) enhanced the separation in capillary zone electrophoresis (raw fused-silica) of standard proteins such as α-chym.....
Document: As native and modified CDs are able to complex some amino acids which constitute peptides and proteins, these molecules can be useful for their separation by capillary zone electrophoresis. In this context, Rathore and Horváth reported that carboxymethyl-β-CD (CM-β-CD) in the electrophoretic medium (aqueous buffer solution, pH 2.5) enhanced the separation in capillary zone electrophoresis (raw fused-silica) of standard proteins such as α-chymotrypsinogen A, cytochrome c, lysozyme and ribonuclease A [90] . The obtained results proved that the separation of peptides and proteins can be enhanced by adding CDs to the electrophoretic medium. Unfortunately, only certain CDs can be used as selectivity enhancers. Indeed, in contrast to CM-β-CD, the addition of DM-β-CD had no effect on the separation of the mentioned proteins and peptides.
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