Author: Rhein, Bethany A.; Powers, Linda S.; Rogers, Kai; Anantpadma, Manu; Singh, Brajesh K.; Sakurai, Yasuteru; Bair, Thomas; Miller-Hunt, Catherine; Sinn, Patrick; Davey, Robert A.; Monick, Martha M.; Maury, Wendy
Title: Interferon-? Inhibits Ebola Virus Infection Document date: 2015_11_12
ID: 10bu7iwg_36
Snippet: These in vivo studies suggest that IFNγ may serve as an effective prophylactic and/or therapeutic drug against EBOV infection. Several different IFNs are currently FDA approved to treat a variety of infections and autoimmune disorders. Type I IFNs have been used clinically as therapeutics against both hepatitis B and C infections [73, 74] , but showed mixed efficacy against EBOV infection in NHPs [11] [12] [13] . The antiviral effects of IFNγ a.....
Document: These in vivo studies suggest that IFNγ may serve as an effective prophylactic and/or therapeutic drug against EBOV infection. Several different IFNs are currently FDA approved to treat a variety of infections and autoimmune disorders. Type I IFNs have been used clinically as therapeutics against both hepatitis B and C infections [73, 74] , but showed mixed efficacy against EBOV infection in NHPs [11] [12] [13] . The antiviral effects of IFNγ are less well-studied, but this protein is a FDA-approved therapy for chronic granulomatous disease and osteopetrosis [75, 76] . Chronic granulomatous patients receive IFNγ three times weekly to prevent infections, which can serve as life-long protective treatment in these patients [77, 78] . The established safety and effectiveness of IFNγ against these disorders and the ability of IFNγ to profoundly inhibit EBOV infection in our studies suggest that IFNγ may serve as an EBOV antiviral therapy.
Search related documents:
Co phrase search for related documents- antiviral effect and ebov infection: 1, 2, 3
- antiviral effect and established safety: 1, 2
- antiviral effect and IFNγ ability: 1
- antiviral effect and IFNγ antiviral effect: 1, 2, 3
- antiviral effect and protective treatment: 1
- antiviral effect and therapeutic drug: 1, 2, 3, 4, 5, 6, 7
- antiviral effect and type ifn: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30
- antiviral effect and vivo study: 1, 2, 3, 4, 5, 6, 7
- antiviral therapy and different ifn: 1, 2
- antiviral therapy and ebov infection: 1
- antiviral therapy and protective treatment: 1, 2, 3, 4, 5
- antiviral therapy and therapeutic drug: 1, 2, 3, 4, 5, 6, 7, 8
- antiviral therapy and type ifn: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- antiviral therapy and vivo study: 1, 2, 3
- autoimmune disorder and therapeutic drug: 1
- autoimmune disorder and type ifn: 1
- autoimmune disorder and vivo study: 1
Co phrase search for related documents, hyperlinks ordered by date