Author: Kumar, Satyendra; Arankalle, Vidya A.
Title: Intracranial Administration of P Gene siRNA Protects Mice from Lethal Chandipura Virus Encephalitis Document date: 2010_1_7
ID: 1mzq227n_64
Snippet: The gene profiling results clearly demonstrate that none of the genes modulated during the course of CHPV infection were affected in P-2 siRNA treated mice confirming that the siRNA did not allow replication of CHPV (real time and histopathology also scored the brains as negative for CHPV) and therefore did not lead to the cascade of immune reactions leading either to recovery or death. Absence of anti-CHP antibodies provides similar evidence......
Document: The gene profiling results clearly demonstrate that none of the genes modulated during the course of CHPV infection were affected in P-2 siRNA treated mice confirming that the siRNA did not allow replication of CHPV (real time and histopathology also scored the brains as negative for CHPV) and therefore did not lead to the cascade of immune reactions leading either to recovery or death. Absence of anti-CHP antibodies provides similar evidence.
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