Selected article for: "cytokine induction and virus infection"
Author: He, Biao; Fu, Yuhong; Xia, Shuai; Yu, Fei; Wang, Qian; Lu, Lu; Jiang, Shibo
Title: Intranasal application of polyethyleneimine suppresses influenza virus infection in mice
  • Document date: 2016_4_27
    • ID: 0rg6n7fr_2
    Snippet: Cholera toxin (CT), which acts as a mucosal adjuvant to stimulate mucosal and systemic immune responses, has the potential for intranasal application as an immunotherapeutic against infection by respiratory viruses. 1 However, CT can exacerbate lung pathology after influenza virus infection through the induction of IL-17, a potent proinflammatory cytokine, because co-administration of an IL-17RA neutralizing antibody with CT attenuates lung patho.....
    Document: Cholera toxin (CT), which acts as a mucosal adjuvant to stimulate mucosal and systemic immune responses, has the potential for intranasal application as an immunotherapeutic against infection by respiratory viruses. 1 However, CT can exacerbate lung pathology after influenza virus infection through the induction of IL-17, a potent proinflammatory cytokine, because co-administration of an IL-17RA neutralizing antibody with CT attenuates lung pathology and increases protection against influenza virus infection. 2 Therefore, we hypothesized that intranasal application of a mucosal stimulant that induces antiviral cytokines, except IL-17, may be effective against influenza virus infection.

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