Author: Elste, James; Kaltenbach, Dominik; Patel, Vraj R.; Nguyen, Max T.; Sharthiya, Harsh; Tandon, Ritesh; Mehta, Satish K.; Volin, Michael V.; Fornaro, Michele; Tiwari, Vaibhav; Desai, Umesh R.
Title: Inhibition of Human Cytomegalovirus Entry into Host Cells through A Pleiotropic Small Molecule Document date: 2020_2_29
ID: 031ro01b_39
Snippet: In summary, our results provide the first evidence in support of pleiotropicity as a valuable approach for discovering anti-HCMV agents. We project that by simultaneously blocking multiple steps involved in HCMV entry and spread, SPGG holds good promise for future drug development. . This recombinant derivative of the Towne strain carries and expresses the E. coli lacZ gene. HCMV strain AD169 (ATCC VR-538) was also purchased from ATCC. HCMV strai.....
Document: In summary, our results provide the first evidence in support of pleiotropicity as a valuable approach for discovering anti-HCMV agents. We project that by simultaneously blocking multiple steps involved in HCMV entry and spread, SPGG holds good promise for future drug development. . This recombinant derivative of the Towne strain carries and expresses the E. coli lacZ gene. HCMV strain AD169 (ATCC VR-538) was also purchased from ATCC. HCMV strain BAD32GFP (from the Tandon lab), is an AD169 derivative fused with green fluorescent protein (GFP) [76] . Viral stocks were propagated in HFF-1 cells and titers were determined by plaque and immunofluorescence assays and the resulting stocks were stored at −80 • C.
Search related documents:
Co phrase search for related documents- drug development and future drug development: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- drug development and green fluorescent: 1, 2, 3
- drug development and green fluorescent protein: 1, 2, 3
- drug development and hcmv entry: 1
- drug development and immunofluorescence assay: 1, 2
- drug development and immunofluorescence assay plaque: 1
- GFP green fluorescent protein and green fluorescent: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- GFP green fluorescent protein and green fluorescent protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- GFP green fluorescent protein and hcmv entry: 1, 2
- GFP green fluorescent protein and lacz gene: 1
- green fluorescent and hcmv entry: 1, 2
- green fluorescent and immunofluorescence assay: 1, 2, 3
- green fluorescent and lacz gene: 1
- green fluorescent protein and hcmv entry: 1, 2
- green fluorescent protein and immunofluorescence assay: 1, 2
- green fluorescent protein and lacz gene: 1
Co phrase search for related documents, hyperlinks ordered by date