Author: Elste, James; Kaltenbach, Dominik; Patel, Vraj R.; Nguyen, Max T.; Sharthiya, Harsh; Tandon, Ritesh; Mehta, Satish K.; Volin, Michael V.; Fornaro, Michele; Tiwari, Vaibhav; Desai, Umesh R.
Title: Inhibition of Human Cytomegalovirus Entry into Host Cells through A Pleiotropic Small Molecule Document date: 2020_2_29
ID: 031ro01b_39
Snippet: In summary, our results provide the first evidence in support of pleiotropicity as a valuable approach for discovering anti-HCMV agents. We project that by simultaneously blocking multiple steps involved in HCMV entry and spread, SPGG holds good promise for future drug development. . This recombinant derivative of the Towne strain carries and expresses the E. coli lacZ gene. HCMV strain AD169 (ATCC VR-538) was also purchased from ATCC. HCMV strai.....
Document: In summary, our results provide the first evidence in support of pleiotropicity as a valuable approach for discovering anti-HCMV agents. We project that by simultaneously blocking multiple steps involved in HCMV entry and spread, SPGG holds good promise for future drug development. . This recombinant derivative of the Towne strain carries and expresses the E. coli lacZ gene. HCMV strain AD169 (ATCC VR-538) was also purchased from ATCC. HCMV strain BAD32GFP (from the Tandon lab), is an AD169 derivative fused with green fluorescent protein (GFP) [76] . Viral stocks were propagated in HFF-1 cells and titers were determined by plaque and immunofluorescence assays and the resulting stocks were stored at −80 • C.
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