Author: Suddala, Krishna C.; Lee, Christine C.; Meraner, Paul; Marin, Mariana; Markosyan, Ruben M.; Desai, Tanay M.; Cohen, Fredric S.; Brass, Abraham L.; Melikyan, Gregory B.
Title: Interferon-induced transmembrane protein 3 blocks fusion of sensitive but not resistant viruses by partitioning into virus-carrying endosomes Document date: 2019_1_14
ID: 15wxk8lt_38
Snippet: Through constructing a functional fluorescently tagged IFITM3 protein, we were able to visualize its dynamic distribution in living cells, in the context of single virus entry and fusion. Imaging experiments demonstrate that IAV restriction involves virus co-trafficking with IFITM3-containing endosomes that can culminate in lipid mixing (hemifusion) but does not progress to complete fusion (viral content release). This important finding, along wi.....
Document: Through constructing a functional fluorescently tagged IFITM3 protein, we were able to visualize its dynamic distribution in living cells, in the context of single virus entry and fusion. Imaging experiments demonstrate that IAV restriction involves virus co-trafficking with IFITM3-containing endosomes that can culminate in lipid mixing (hemifusion) but does not progress to complete fusion (viral content release). This important finding, along with our previous work [17, 30, 35] , strongly supports a proximity model for virus restriction, as opposed to alternative models that involve, for example, dysregulation of cholesterol transport from late endosomes [18, 39] . Also importantly, we documented the "avoidance" mechanism of
Search related documents:
Co phrase search for related documents- alternative model and previous work: 1
- cholesterol transport and late endosome: 1
- cholesterol transport and virus entry: 1, 2, 3
- complete fusion and proximity model: 1
- complete fusion and virus entry: 1, 2, 3, 4, 5
Co phrase search for related documents, hyperlinks ordered by date