Author: Shabman, Reed S.; Shrivastava, Susmita; Tsibane, Tshidi; Attie, Oliver; Jayaprakash, Anitha; Mire, Chad E.; Dilley, Kari E.; Puri, Vinita; Stockwell, Timothy B.; Geisbert, Thomas W.; Sachidanandam, Ravi; Basler, Christopher F.
Title: Isolation and Characterization of a Novel Gammaherpesvirus from a Microbat Cell Line Document date: 2016_2_17
ID: 1a9u53za_1
Snippet: Bats are of significant interest as reservoirs for zoonotic viral pathogens; however, tools to dissect bat-virus interactions are limited in availability. This study serendipitously identified, in an established bat cell line, a fully replicationcompetent gammaherpesvirus; determined the complete genome sequence of the virus; and generated a viral transcript map. This virus can replicate in select human and nonhuman primate cell lines. However, a.....
Document: Bats are of significant interest as reservoirs for zoonotic viral pathogens; however, tools to dissect bat-virus interactions are limited in availability. This study serendipitously identified, in an established bat cell line, a fully replicationcompetent gammaherpesvirus; determined the complete genome sequence of the virus; and generated a viral transcript map. This virus can replicate in select human and nonhuman primate cell lines. However, analyses of viral sequences support a bat origin for this virus; we therefore refer to the virus as bat gammaherpesvirus 8 (BGHV8). The viral genome contains unique open reading frames that likely encode modulators of bat innate and adaptive immune signaling pathways and expresses viral miRNAs. The virus and its gene products should provide a unique tool to dissect both bat and gammaherpesvirus biology.
Search related documents:
Co phrase search for related documents- cell line and gammaherpesvirus bat: 1, 2, 3, 4, 5, 6
- cell line and gammaherpesvirus bat biology: 1
- cell line and gammaherpesvirus bat biology dissect: 1
- cell line and gene product: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- cell line and gene product virus: 1
- cell line and genome sequence: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- cell line and pathway signaling: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44
- cell line and primate cell line: 1, 2, 3, 4, 5, 6
- cell line and reading frame: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- cell line and significant interest: 1, 2
- cell line and transcript map: 1, 2, 3
- cell line and unique tool: 1
- cell line and unique tool provide: 1
- cell line and viral genome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36
- cell line and viral pathogen: 1, 2, 3
- cell line and viral sequence: 1, 2, 3, 4, 5, 6, 7, 8
- cell line and viral transcript map: 1
- cell line and virus bat origin: 1, 2, 3
- cell line and virus bat origin support: 1, 2
Co phrase search for related documents, hyperlinks ordered by date