Author: Wang, Xiaoli; Wang, Jiao; Zhang, Wenmei; Li, Boye; Zhu, Ying; Hu, Qin; Yang, Yishu; Zhang, Xiaoguang; Yan, Hong; Zeng, Yi
Title: Inhibition of Human Immunodeficiency Virus Type 1 Entry by a Keggin Polyoxometalate Document date: 2018_5_16
ID: 1ghbutov_49
Snippet: In summary, our results revealed a safe, potent and broad spectrum antiretroviral activity of PT-1 (K 6 HPTi 2 W 10 O 40 ). The data suggested that PT-1 functioned during an early stage of infection, partially by directly interacting with the gp41 NHR and blocking the gp120-binding domain of the CD4 receptor. These findings suggest that PT-1 may be a promising drug candidate for the treatment of HIV-1......
Document: In summary, our results revealed a safe, potent and broad spectrum antiretroviral activity of PT-1 (K 6 HPTi 2 W 10 O 40 ). The data suggested that PT-1 functioned during an early stage of infection, partially by directly interacting with the gp41 NHR and blocking the gp120-binding domain of the CD4 receptor. These findings suggest that PT-1 may be a promising drug candidate for the treatment of HIV-1.
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