Selected article for: "administration route and intramuscular injection"
Author: Rhein, Bethany A.; Powers, Linda S.; Rogers, Kai; Anantpadma, Manu; Singh, Brajesh K.; Sakurai, Yasuteru; Bair, Thomas; Miller-Hunt, Catherine; Sinn, Patrick; Davey, Robert A.; Monick, Martha M.; Maury, Wendy
Title: Interferon-? Inhibits Ebola Virus Infection
  • Document date: 2015_11_12
    • ID: 10bu7iwg_24
    Snippet: Previous studies have demonstrated that IFNγ treatment administered by intramuscular (i.m.) injection allows for slower release and an extended half-life of the drug [46] . Further, this injection route is utilized in many clinical therapeutics. Thus, we investigated the ability of this administration route to protect mice against lethal EBOV GP/rVSV. Mice given 10 μg of IFNγ by i.m. injection 24 hours prior to EBOV GP/rVSV infection significa.....
    Document: Previous studies have demonstrated that IFNγ treatment administered by intramuscular (i.m.) injection allows for slower release and an extended half-life of the drug [46] . Further, this injection route is utilized in many clinical therapeutics. Thus, we investigated the ability of this administration route to protect mice against lethal EBOV GP/rVSV. Mice given 10 μg of IFNγ by i.m. injection 24 hours prior to EBOV GP/rVSV infection significantly protected against lethal challenge (Fig 5D) .

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