Author: Xu, Yingying; Yuen, Pak-Wai; Lam, Jenny Ka-Wing
Title: Intranasal DNA Vaccine for Protection against Respiratory Infectious Diseases: The Delivery Perspectives Document date: 2014_7_10
ID: 0bma2749_36
Snippet: DNA vaccines can potentially solve the mismatch problem by shortening the lag time [96] , which is particularly useful when facing influenza pandemic. In addition, the strategy of combined immunization with DNA vaccines encoding surface protein (e.g., HA) and internal protein (NP and M1) could offer better protection against influenza virus than single DNA vaccine alone in mice and ferrets [97] [98] [99] [100] . With the success of DNA vaccines i.....
Document: DNA vaccines can potentially solve the mismatch problem by shortening the lag time [96] , which is particularly useful when facing influenza pandemic. In addition, the strategy of combined immunization with DNA vaccines encoding surface protein (e.g., HA) and internal protein (NP and M1) could offer better protection against influenza virus than single DNA vaccine alone in mice and ferrets [97] [98] [99] [100] . With the success of DNA vaccines in various animal models, several phase I & II clinical trials on DNA vaccine against influenza have been being carried out. Results so far have been encouraging, demonstrating both safety and immunogenic response in human [32, 52, 101] .
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