Author: He, Biao; Fu, Yuhong; Xia, Shuai; Yu, Fei; Wang, Qian; Lu, Lu; Jiang, Shibo
Title: Intranasal application of polyethyleneimine suppresses influenza virus infection in mice Document date: 2016_4_27
ID: 0rg6n7fr_4
Snippet: To determine the efficacy of PEI against another subtype of influenza virus, we pretreated mice with PBS containing PEI or PBS alone and challenged them with 5 LD 50 influenza virus H3N2 (A/Guizhou/54/89). Mice in the PEI-pretreated group were fully protected against H3N2 challenge, showing no significant body weight loss ( Figure 1E ) and a 100% survival rate, whereas those in the PBS group lost more than 25% of their body weight and showed a 0%.....
Document: To determine the efficacy of PEI against another subtype of influenza virus, we pretreated mice with PBS containing PEI or PBS alone and challenged them with 5 LD 50 influenza virus H3N2 (A/Guizhou/54/89). Mice in the PEI-pretreated group were fully protected against H3N2 challenge, showing no significant body weight loss ( Figure 1E ) and a 100% survival rate, whereas those in the PBS group lost more than 25% of their body weight and showed a 0% survival rate on day 6 post-challenge ( Figure 1F ). Therefore, PEI-mediated protection against influenza virus infection is not subtype-specific.
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