Author: Elste, James; Kaltenbach, Dominik; Patel, Vraj R.; Nguyen, Max T.; Sharthiya, Harsh; Tandon, Ritesh; Mehta, Satish K.; Volin, Michael V.; Fornaro, Michele; Tiwari, Vaibhav; Desai, Umesh R.
Title: Inhibition of Human Cytomegalovirus Entry into Host Cells through A Pleiotropic Small Molecule Document date: 2020_2_29
ID: 031ro01b_8
Snippet: To first assess whether SPGG is toxic to cells typically targeted by HCMV, we studied dosedependence of cell viability. We utilized lactate dehydrogenase (LDH) assay as a surrogate for cell viability, as described in the literature [62] . Briefly, rupture of plasma membranes due to apoptosis, Heparan Sulfate (HS) (M R > 20,000) X = H or SO 3¯; Y = COCH 3 or SO 3S PGG (M R~ 2,178) X = H or SO 3F igure 1. Heparan sulfate (HS) and sulfated pentagal.....
Document: To first assess whether SPGG is toxic to cells typically targeted by HCMV, we studied dosedependence of cell viability. We utilized lactate dehydrogenase (LDH) assay as a surrogate for cell viability, as described in the literature [62] . Briefly, rupture of plasma membranes due to apoptosis, Heparan Sulfate (HS) (M R > 20,000) X = H or SO 3¯; Y = COCH 3 or SO 3S PGG (M R~ 2,178) X = H or SO 3F igure 1. Heparan sulfate (HS) and sulfated pentagalloylglucoside (SPGG). Whereas HS is a linear polymer with an average molecular weight (Mr) of approximately 20,000, SPGG is a globular small molecule with Mr of 2178. HS is a biopolymer; in contrast SPGG is synthesized in 5 steps in excellent yields.
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