Author: Suthar, Mehul S.; Ma, Daphne Y.; Thomas, Sunil; Lund, Jennifer M.; Zhang, Nu; Daffis, Stephane; Rudensky, Alexander Y.; Bevan, Michael J.; Clark, Edward A.; Kaja, Murali-Krishna; Diamond, Michael S.; Gale, Michael
Title: IPS-1 Is Essential for the Control of West Nile Virus Infection and Immunity Document date: 2010_2_5
ID: 094d0rn6_11
Snippet: West Nile virus (WNV) is a mosquito-transmitted RNA virus that has emerged in the Western hemisphere and is now the leading cause of arboviral encephalitis in the United States. However, the virus/host interface that controls WNV pathogenesis is not well understood. Previous studies have established that the innate immune response and interferon (IFN) defenses are essential for controlling virus replication and dissemination. In this study, we as.....
Document: West Nile virus (WNV) is a mosquito-transmitted RNA virus that has emerged in the Western hemisphere and is now the leading cause of arboviral encephalitis in the United States. However, the virus/host interface that controls WNV pathogenesis is not well understood. Previous studies have established that the innate immune response and interferon (IFN) defenses are essential for controlling virus replication and dissemination. In this study, we assessed the importance of the RIG-I like receptor (RLR) signaling pathway in WNV pathogenesis through analysis of mice lacking IPS-1, the central adaptor molecule of RLR signaling. Our studies revealed that IPS-1 is essential for protection against WNV infection and that it regulates processes that control virus replication and triggering of innate immune defenses. We found that IPS-1 plays an important role in establishing adaptive immunity through an innate/adaptive interface that elicits effective antibody responses and controls the expansion of regulatory T cells. Thus, RLRs are essential for pathogen recognition of WNV infection and their signaling programs help orchestrate immune response maturation, regulation of inflammation, and immune homeostasis that define the outcome of WNV infection.
Search related documents:
Co phrase search for related documents- adaptive immunity and innate immune defense: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- adaptive immunity and innate immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- adaptive immunity and interferon IFN defense: 1
- adaptive immunity and lack mouse: 1
- adaptive immunity and pathogen recognition: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- adaptive immunity and pathway signal: 1, 2
- adaptive immunity and previous study: 1, 2, 3
- adaptive immunity and response maturation: 1, 2, 3
- adaptive immunity and RLR receptor: 1, 2
- adaptive immunity and RNA virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- adaptive immunity and triggering virus replication: 1
- adaptive immunity and virus host: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33
- adaptive immunity and virus replication: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26
- adaptive immunity and West Nile virus: 1, 2, 3
- adaptive immunity and WNV infection: 1, 2, 3, 4, 5, 6, 7, 8
- adaptive immunity and WNV infection protection: 1
- adaptive immunity and wnv pathogenesis: 1, 2, 3, 4
- adaptive immunity and wnv pathogenesis control: 1
- adaptive immunity and WNV West Nile virus: 1, 2
Co phrase search for related documents, hyperlinks ordered by date