Author: Priolo, Vito; Martínez-Orellana, Pamela; Pennisi, Maria Grazia; Masucci, Marisa; Prandi, David; Ippolito, Dorotea; Bruno, Federica; Castelli, Germano; Solano-Gallego, Laia
Title: Leishmania infantum-specific IFN-? production in stimulated blood from cats living in areas where canine leishmaniosis is endemic Document date: 2019_3_26
ID: 04ljoezz_3
Snippet: Different feline innate and adaptive immune responses might account for the observed lower prevalence of L. infantum infection as well as clinical leishmaniosis in cats as compared to dogs [7, 14] . It is well recognized that cats appear to be less frequently affected by arthropodborne diseases when compared to dogs, although no important differences are known between the canine and feline immune systems [15] . Interestingly, to the best of our k.....
Document: Different feline innate and adaptive immune responses might account for the observed lower prevalence of L. infantum infection as well as clinical leishmaniosis in cats as compared to dogs [7, 14] . It is well recognized that cats appear to be less frequently affected by arthropodborne diseases when compared to dogs, although no important differences are known between the canine and feline immune systems [15] . Interestingly, to the best of our knowledge, no studies have so far evaluated L. infantum-specific cell-mediated immunity in cats. However, detection of IFN-γ in antigen stimulated whole blood or peripheral blood mononuclear cells (PBMCs) was used in cats to evaluate cellular immune response mechanisms to other pathogens (e.g. feline coronavirus or Toxoplasma gondii) [16] [17] [18] .
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