Author: Shabman, Reed S.; Shrivastava, Susmita; Tsibane, Tshidi; Attie, Oliver; Jayaprakash, Anitha; Mire, Chad E.; Dilley, Kari E.; Puri, Vinita; Stockwell, Timothy B.; Geisbert, Thomas W.; Sachidanandam, Ravi; Basler, Christopher F.
Title: Isolation and Characterization of a Novel Gammaherpesvirus from a Microbat Cell Line Document date: 2016_2_17
ID: 1a9u53za_31
Snippet: Replication-competent BGHV8 and its annotated genome provide a valuable tool to further understand bat-virus interactions. Many of the ORFs described above are likely to modulate apoptosis (e.g., v-FLIP and vBcl-2), cell signaling (the BGHV G-proteincoupled receptors), and cytokine production (e.g., v-OX2). Moreover, inhibition of the cGAS DNA sensing pathway has been linked to KSHV ORF52 (47) , and a corresponding ORF52 is present in BGHV8 (Fig......
Document: Replication-competent BGHV8 and its annotated genome provide a valuable tool to further understand bat-virus interactions. Many of the ORFs described above are likely to modulate apoptosis (e.g., v-FLIP and vBcl-2), cell signaling (the BGHV G-proteincoupled receptors), and cytokine production (e.g., v-OX2). Moreover, inhibition of the cGAS DNA sensing pathway has been linked to KSHV ORF52 (47) , and a corresponding ORF52 is present in BGHV8 (Fig. 4) . In the future, defining how selected BGHV8 ORFs modulate innate and adaptive immune signaling pathways in bats should provide a powerful and unique tool to further understand bat biology.
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