Selected article for: "restriction factor and viral fusion"
Author: Suddala, Krishna C.; Lee, Christine C.; Meraner, Paul; Marin, Mariana; Markosyan, Ruben M.; Desai, Tanay M.; Cohen, Fredric S.; Brass, Abraham L.; Melikyan, Gregory B.
Title: Interferon-induced transmembrane protein 3 blocks fusion of sensitive but not resistant viruses by partitioning into virus-carrying endosomes
  • Document date: 2019_1_14
    • ID: 15wxk8lt_29
    Snippet: We next assessed the basis for LASV resistance to IFITM3 restriction. A549-IFITM3-imTFP1 cells were infected with LASVpp labeled with mCherry-2xCL-YFP-Vpr, as above. Single particle imaging revealed that LASVpp did not co-traffic with IFITM3-imTFP1-positive endosomes and that subsequent viral fusion occurred at sites devoid of this fluorescent restriction factor (Fig 6A, S11 Movie) . Analysis of single LASVpp fluorescence intensities in A549-IFIT.....
    Document: We next assessed the basis for LASV resistance to IFITM3 restriction. A549-IFITM3-imTFP1 cells were infected with LASVpp labeled with mCherry-2xCL-YFP-Vpr, as above. Single particle imaging revealed that LASVpp did not co-traffic with IFITM3-imTFP1-positive endosomes and that subsequent viral fusion occurred at sites devoid of this fluorescent restriction factor (Fig 6A, S11 Movie) . Analysis of single LASVpp fluorescence intensities in A549-IFIT-M3-imTFP1 cells shows a typical Type II fusion event which occurs within an endosome lacking above-background amounts of IFITM3-imTFP1 (Fig 6B) .

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