Selected article for: "diarrhea cause and RV infection"
Author: Lee, Sanghyun; Baldridge, Megan T.
Title: Interferon-Lambda: A Potent Regulator of Intestinal Viral Infections
  • Document date: 2017_6_30
    • ID: 0bz297i0_7
    Snippet: Rotaviruses are double-stranded RNA viruses of the Reoviridae family and a major cause of severe diarrhea in children worldwide (39) . RV infection exhibits a preferential tropism for IECs of the small intestinal villi in humans and mice (40) . Several groups have reported antiviral effects of IFN-λ against RV in mouse models (16, 24, 41) . Infection by a murine RV, EDIM-RV, induces IFN-λ in the small intestine, and endogenous IFN-λ suppresses.....
    Document: Rotaviruses are double-stranded RNA viruses of the Reoviridae family and a major cause of severe diarrhea in children worldwide (39) . RV infection exhibits a preferential tropism for IECs of the small intestinal villi in humans and mice (40) . Several groups have reported antiviral effects of IFN-λ against RV in mouse models (16, 24, 41) . Infection by a murine RV, EDIM-RV, induces IFN-λ in the small intestine, and endogenous IFN-λ suppresses intestinal viral replication (16, 41) . RIG-I and MDA5

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