Author: Van der Gucht, Winke; Stobbelaar, Kim; Govaerts, Matthias; Mangodt, Thomas; Barbezange, Cyril; Leemans, Annelies; De Winter, Benedicte; Van Gucht, Steven; Caljon, Guy; Maes, Louis; De Dooy, Jozef; Jorens, Philippe; Smet, Annemieke; Cos, Paul; Verhulst, Stijn; Delputte, Peter L.
Title: Isolation and Characterization of Clinical RSV Isolates in Belgium during the Winters of 2016–2018 Document date: 2019_11_6
ID: 0imlae98_58
Snippet: We have observed differences in characteristics between viruses which were isolated from children in one RSV season, such as in vitro viral replication kinetics in cell lines, infectious virus production, thermal stability, fusion capacity and neutralization-sensitivity. Additionally, mucin mRNA expression was assessed and revealed generally minor differences between the different clinical isolates. Furthermore, a comparison of the clinical isola.....
Document: We have observed differences in characteristics between viruses which were isolated from children in one RSV season, such as in vitro viral replication kinetics in cell lines, infectious virus production, thermal stability, fusion capacity and neutralization-sensitivity. Additionally, mucin mRNA expression was assessed and revealed generally minor differences between the different clinical isolates. Furthermore, a comparison of the clinical isolates to the reference strains RSV A2 and RSV B1 reveal overall no major differences. Clinical isolates can replicate either faster or slower in cell lines, generally have a lower thermal stability, and have differences in fusion capacity and mucin expression.
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