Author: Lee, Yu-Ching; Tsai, Keng-Chang; Leu, Sy-Jye; Wang, Tuan-Jen; Liu, Chia-Yu; Yang, Yi-Yuan
Title: Isolation, Characterization, and Molecular Modeling of a Rheumatoid Factor from a Hepatitis C Virus Infected Patient with Sjögren's Syndrome Document date: 2013_12_30
ID: 0zsn4lu3_21
Snippet: Owing to the light chains of RFL11 and RF61 antibodies with high homology CDRs, RFL11 and RF61 may bind to the similar epitope of IgG Fc (see Table 1 ). The complex structural model of RFL11 interacting with IgG Fc antigen was built by aligning RFL11 and the complex structure of RF61-IgG Fc to obtain an RFL11-IgG Fc complex instead of using docking methods [23] to avoid uncertain orientation of the interaction between these two proteins. The CDRs.....
Document: Owing to the light chains of RFL11 and RF61 antibodies with high homology CDRs, RFL11 and RF61 may bind to the similar epitope of IgG Fc (see Table 1 ). The complex structural model of RFL11 interacting with IgG Fc antigen was built by aligning RFL11 and the complex structure of RF61-IgG Fc to obtain an RFL11-IgG Fc complex instead of using docking methods [23] to avoid uncertain orientation of the interaction between these two proteins. The CDRs of RFL11 interacting with IgG Fc antigen were energy minimized using Dreidinglike force field from Discovery Studio v.3.5 for a few steps to remove any inappropriate contacts and obtain a reliable complex structure.
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