Selected article for: "antibody heavy chain and light chain"
Author: Lee, Yu-Ching; Tsai, Keng-Chang; Leu, Sy-Jye; Wang, Tuan-Jen; Liu, Chia-Yu; Yang, Yi-Yuan
Title: Isolation, Characterization, and Molecular Modeling of a Rheumatoid Factor from a Hepatitis C Virus Infected Patient with Sjögren's Syndrome
  • Document date: 2013_12_30
    • ID: 0zsn4lu3_19
    Snippet: Modeling. RFL11, an anti-human IgG Fc Fab, was found to possess the highest affinity among several clones screened in this study and modeled as an scFv scaffold using the homology modeling program. To obtain a reliable light chain model for RFL11, sequence alignment of the light chains of RFL11 and RF61 antibodies (PDB id: 2J6E) [13] was used, showing 97.6% or 92.4% of homology, exclusive or inclusive of CDRs, respectively. Similarly, to build th.....
    Document: Modeling. RFL11, an anti-human IgG Fc Fab, was found to possess the highest affinity among several clones screened in this study and modeled as an scFv scaffold using the homology modeling program. To obtain a reliable light chain model for RFL11, sequence alignment of the light chains of RFL11 and RF61 antibodies (PDB id: 2J6E) [13] was used, showing 97.6% or 92.4% of homology, exclusive or inclusive of CDRs, respectively. Similarly, to build the heavy chain model of RFL11, the heavy chain sequence showed a high similarity when compared with another antibody (PDB id: 3H0T) [22] , exclusive (98.8%) or inclusive (91.7%) CDRs.

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