Selected article for: "antibody expression and human therapeutic"
Author: Lee, Yu-Ching; Tsai, Keng-Chang; Leu, Sy-Jye; Wang, Tuan-Jen; Liu, Chia-Yu; Yang, Yi-Yuan
Title: Isolation, Characterization, and Molecular Modeling of a Rheumatoid Factor from a Hepatitis C Virus Infected Patient with Sjögren's Syndrome
  • Document date: 2013_12_30
    • ID: 0zsn4lu3_3
    Snippet: Human monoclonal antibodies were in great demand for the therapeutic and diagnostic purposes. The combinatorial methodologies have been improved rapidly and dramatically [14, 15] . Particularly, the expression of combinatorial antibody Fab fragments on phage surfaces allows for rapid enrichment of the desired Fab fragments against target antigens. This technique has been used to study pathogenic autoantibodies in various human autoimmune disorder.....
    Document: Human monoclonal antibodies were in great demand for the therapeutic and diagnostic purposes. The combinatorial methodologies have been improved rapidly and dramatically [14, 15] . Particularly, the expression of combinatorial antibody Fab fragments on phage surfaces allows for rapid enrichment of the desired Fab fragments against target antigens. This technique has been used to study pathogenic autoantibodies in various human autoimmune disorders [16] [17] [18] . To study IgG RFs in Sjögren's syndrome patients with HCV infection, we used the combinatorial antibody technique and characterized isolated RF Fab molecules. The results allow us to further define the pathogenic role of RFs played in autoimmune diseases complicated with viral infection. In addition, from the insight on the genetic level, clues are expected to reveal the association of the cause of autoimmune disorders.

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