Author: Elste, James; Kaltenbach, Dominik; Patel, Vraj R.; Nguyen, Max T.; Sharthiya, Harsh; Tandon, Ritesh; Mehta, Satish K.; Volin, Michael V.; Fornaro, Michele; Tiwari, Vaibhav; Desai, Umesh R.
Title: Inhibition of Human Cytomegalovirus Entry into Host Cells through A Pleiotropic Small Molecule Document date: 2020_2_29
ID: 031ro01b_37
Snippet: Another reason behind the excitement with SPGG is the inhibition of the immediate early viral gene expression in two different cell lines. As yet no sulfated biopolymer has been demonstrated to display this phenomenon. This finding is important because the products of immediate early genes are essential for viral DNA replication. Therefore, SPGG-like small molecule that display this phenomenon may offer novel strategies for inhibiting HCMV. Likew.....
Document: Another reason behind the excitement with SPGG is the inhibition of the immediate early viral gene expression in two different cell lines. As yet no sulfated biopolymer has been demonstrated to display this phenomenon. This finding is important because the products of immediate early genes are essential for viral DNA replication. Therefore, SPGG-like small molecule that display this phenomenon may offer novel strategies for inhibiting HCMV. Likewise, the reduction in viral spread adds more value to the inhibitory role of SPGG. It is important to note that the teratogenicity and toxicity of available HCMV antiviral agents make treatment options during early development markedly limited.
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