Author: Elste, James; Kaltenbach, Dominik; Patel, Vraj R.; Nguyen, Max T.; Sharthiya, Harsh; Tandon, Ritesh; Mehta, Satish K.; Volin, Michael V.; Fornaro, Michele; Tiwari, Vaibhav; Desai, Umesh R.
Title: Inhibition of Human Cytomegalovirus Entry into Host Cells through A Pleiotropic Small Molecule Document date: 2020_2_29
ID: 031ro01b_41
Snippet: The synthesis of SPGG has been reported earlier [77] . Briefly, it involves five steps starting from commercially available raw materials and culminating in a microwave-based sulfation reaction. The overall yield of this five step process is~40%. The characterization of SPGG and its variants have been described in a later report [61] . The variant of SPGG used in this report has defined molecular composition of septa-(6%), octa-(17%), nona-(21%),.....
Document: The synthesis of SPGG has been reported earlier [77] . Briefly, it involves five steps starting from commercially available raw materials and culminating in a microwave-based sulfation reaction. The overall yield of this five step process is~40%. The characterization of SPGG and its variants have been described in a later report [61] . The variant of SPGG used in this report has defined molecular composition of septa-(6%), octa-(17%), nona-(21%), deca-(45%), undeca-(11%), and dodeca-(3%) sulfated species (average molecular weight 2178; see Al-Horani et al., 2013), which has been reproducibly synthesized and characterized using advanced LC-MS/MS methods. This SPGG variant is most studied variant so far through characterization of anti-thrombotic, anti-HSV and anti-Chlamydia activity profiles [66] .
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