Author: Wang, Xiaoli; Wang, Jiao; Zhang, Wenmei; Li, Boye; Zhu, Ying; Hu, Qin; Yang, Yishu; Zhang, Xiaoguang; Yan, Hong; Zeng, Yi
Title: Inhibition of Human Immunodeficiency Virus Type 1 Entry by a Keggin Polyoxometalate Document date: 2018_5_16
ID: 1ghbutov_38_1
Snippet: nity with the N36 peptide in SPR assays, with PT-1 bound to immobilized N36 showing an average KD of 42.8 nM ( Figure 4A ). Taken together, these data revealed that PT-1 inhibited HIV-1 Env-mediated entry by blocking the gp120 binding site of the CD4 receptor and interacting with the viral gp41 NHR......
Document: nity with the N36 peptide in SPR assays, with PT-1 bound to immobilized N36 showing an average KD of 42.8 nM ( Figure 4A ). Taken together, these data revealed that PT-1 inhibited HIV-1 Env-mediated entry by blocking the gp120 binding site of the CD4 receptor and interacting with the viral gp41 NHR.
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