Author: Xu, Yingying; Yuen, Pak-Wai; Lam, Jenny Ka-Wing
Title: Intranasal DNA Vaccine for Protection against Respiratory Infectious Diseases: The Delivery Perspectives Document date: 2014_7_10
ID: 0bma2749_1
Snippet: Majority of the current licensed vaccines for the prevention of infectious diseases are live-attenuated vaccines, inactivated vaccines, or subunit vaccines. Each of them has its pros and cons. The live-attenuated vaccines can stimulate both cellular and humoral immune responses, and induce prolonged immunity that closely resembles natural infection. However, there are safety concerns associated with the use of the live attenuated virus or bacteri.....
Document: Majority of the current licensed vaccines for the prevention of infectious diseases are live-attenuated vaccines, inactivated vaccines, or subunit vaccines. Each of them has its pros and cons. The live-attenuated vaccines can stimulate both cellular and humoral immune responses, and induce prolonged immunity that closely resembles natural infection. However, there are safety concerns associated with the use of the live attenuated virus or bacterial vaccines as they may revert to disease causing forms. It is also difficult to target multiple viral subtypes or pathogens using live-attenuated vaccines. Inactivated and subunit vaccines are safer options as they cannot replicate and do not cause disease. They confer protection mainly through humoral immune responses with little or no cellular immunity. The induced immunity lasts for a shorter period of time; therefore, supplemental doses are always required.
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