Selected article for: "particle size and surface particle size"
Author: Xu, Yingying; Yuen, Pak-Wai; Lam, Jenny Ka-Wing
Title: Intranasal DNA Vaccine for Protection against Respiratory Infectious Diseases: The Delivery Perspectives
  • Document date: 2014_7_10
    • ID: 0bma2749_49
    Snippet: High versatility is one of the attractive features of polymer-based DNA delivery systems. Cationic polymers can form complexes (polyplexes) with nucleic acids through electrostatic interaction. Polymer synthesis is relatively cheap and is easy to scale-up. Particle size and surface properties of polymeric particles can be controlled by using different polymers and fabrication methods in order to optimize their cellular uptake and transfection eff.....
    Document: High versatility is one of the attractive features of polymer-based DNA delivery systems. Cationic polymers can form complexes (polyplexes) with nucleic acids through electrostatic interaction. Polymer synthesis is relatively cheap and is easy to scale-up. Particle size and surface properties of polymeric particles can be controlled by using different polymers and fabrication methods in order to optimize their cellular uptake and transfection efficiency. The polymeric particles can also be modified to include specific function groups or ligands to enhance immune responses.

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