Author: Warner, Nikole L.; Jokinen, Jenny D.; Beier, Juliane I.; Sokoloski, Kevin J.; Lukashevich, Igor S.
Title: Mammarenaviral Infection Is Dependent on Directional Exposure to and Release from Polarized Intestinal Epithelia Document date: 2018_2_10
ID: 1t8jmunt_20
Snippet: As described earlier, the gastrointestinal tract is one of the major gates of arenavirus entry during rodent-to-human transmission [5, 10, 11] . During transmission, epithelial barriers may affect pathogenicity of the OW arenaviruses [23, 40] . To assess the role of the intestinal epithelial barrier during infections of LCMV strains with different pathogenic potential for NHPs, the polarized Caco-2 cells were exposed either apically or basolatera.....
Document: As described earlier, the gastrointestinal tract is one of the major gates of arenavirus entry during rodent-to-human transmission [5, 10, 11] . During transmission, epithelial barriers may affect pathogenicity of the OW arenaviruses [23, 40] . To assess the role of the intestinal epithelial barrier during infections of LCMV strains with different pathogenic potential for NHPs, the polarized Caco-2 cells were exposed either apically or basolaterally to the aforementioned OW arenaviruses. To verify the integrity of the polarized monolayer during the experiment, TEER was measured regularly, and the apical and basolateral supernatants were collected every 24 h for a period of 5 days.
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