Author: Leclercq, Loïc
Title: Interactions between cyclodextrins and cellular components: Towards greener medical applications? Document date: 2016_12_7
ID: 16pzlvzz_62
Snippet: Moreover, α-CD can also be used to reduce LDL cholesterol and alters plasma fatty acid profile [134, 135] . In 2016, a double blind, placebo-controlled clinical trial has been published on the effect of oral α-CD [136] . After 12 to 14 weeks, a daily 6 gram dose of α-CD allowed to reduce fasting plasma glucose levels (1.6%, p < 0.05) and insulin index (11%, p < 0.04) in 75 healthy men and women. In addition, the LDL cholesterol levels were red.....
Document: Moreover, α-CD can also be used to reduce LDL cholesterol and alters plasma fatty acid profile [134, 135] . In 2016, a double blind, placebo-controlled clinical trial has been published on the effect of oral α-CD [136] . After 12 to 14 weeks, a daily 6 gram dose of α-CD allowed to reduce fasting plasma glucose levels (1.6%, p < 0.05) and insulin index (11%, p < 0.04) in 75 healthy men and women. In addition, the LDL cholesterol levels were reduced by 10% (p < 0.045) compared with placebo. This CD was well tolerated and no serious adverse events were reported. Only about 8% of patients treated with α-CD reported side effect such as minor gastrointestinal symptoms (3% for the placebo). Consequently, the use of α-CD, safe and well tolerated, showed a reduction in LDL cholesterol, and an improvement of fasting plasma glucose.
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