Author: Rhein, Bethany A.; Powers, Linda S.; Rogers, Kai; Anantpadma, Manu; Singh, Brajesh K.; Sakurai, Yasuteru; Bair, Thomas; Miller-Hunt, Catherine; Sinn, Patrick; Davey, Robert A.; Monick, Martha M.; Maury, Wendy
Title: Interferon-? Inhibits Ebola Virus Infection Document date: 2015_11_12
ID: 10bu7iwg_21
Snippet: Consistent with reduced morbidity and mortality in the EBOV GP/rVSV infected, IFNγtreated mice, mice treated with 3.3 μg of IFNγ at 24 hour before infection had dramatically lower EBOV GP/rVSV viremia at day 2 of infection ( Fig 5B) . Little to no detectable viral load was observed in liver, peritoneal lymph nodes or brain, of the pre-treated mice with somewhat higher levels of virus present in the spleen. Similar trends were observed in mice .....
Document: Consistent with reduced morbidity and mortality in the EBOV GP/rVSV infected, IFNγtreated mice, mice treated with 3.3 μg of IFNγ at 24 hour before infection had dramatically lower EBOV GP/rVSV viremia at day 2 of infection ( Fig 5B) . Little to no detectable viral load was observed in liver, peritoneal lymph nodes or brain, of the pre-treated mice with somewhat higher levels of virus present in the spleen. Similar trends were observed in mice treated with IFNγ 2 hours following EBOV GP/rVSV infection (Fig 5B) , but splenic virus loads were higher in these mice, suggesting that some virus had trafficked to the spleen by 2 hours following inoculation. Nonetheless, IFNγ treatment still controlled virus titers in other organs.
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