Author: Zhang, Qingshui; Cao, Yanxin; Wang, Jun; Fu, Guanghua; Sun, Mengxu; Zhang, Lijiao; Meng, Li; Cui, Guolin; Huang, Yu; Hu, Xueying; Su, Jingliang
Title: Isolation and characterization of an astrovirus causing fatal visceral gout in domestic goslings Document date: 2018_4_19
ID: 1k5jucae_8
Snippet: To determine the potential genetic mutation(s) that might occur during the goose embryo passage, the initial virus genome was sequenced using the total RNA extracted from the clinical case tissue homogenate. Nucleotide differences between the initial virus genome and that of the fourth embryo-passaged isolate was shown in Table S1 . A single-mutation exhibited in the ORF2 gene of the adapted isolate, leading to the amino acid change from R 225 to.....
Document: To determine the potential genetic mutation(s) that might occur during the goose embryo passage, the initial virus genome was sequenced using the total RNA extracted from the clinical case tissue homogenate. Nucleotide differences between the initial virus genome and that of the fourth embryo-passaged isolate was shown in Table S1 . A single-mutation exhibited in the ORF2 gene of the adapted isolate, leading to the amino acid change from R 225 to Q 225 . The potential effect of the mutation on the virus adaptation need to be further evaluated.
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