Selected article for: "anchor residue strong selection detect and escape site"
Author: Palmer, Duncan S.; Turner, Isaac; Fidler, Sarah; Frater, John; Goedhals, Dominique; Goulder, Philip; Huang, Kuan-Hsiang Gary; Oxenius, Annette; Phillips, Rodney; Shapiro, Roger; Vuuren, Cloete van; McLean, Angela R.; McVean, Gil
Title: Mapping the drivers of within-host pathogen evolution using massive data sets
  • Document date: 2019_7_9
    • ID: 100r7w2n_125
    Snippet: B * 18 epitope NETPGIRYQY (sites 137-146 in reverse transcriptase). We detect strong B * 18-dependent selection at the first anchor residue of NETPGIRYQY (site 138) [35, 37] . We do not detect selection at the other escape site. Further investigation of the literature reveals that the 'diminished response' induced by a variant at this site is actually recognised to much the same levels as the wild type epitope, and precedes outgrowth of the singl.....
    Document: B * 18 epitope NETPGIRYQY (sites 137-146 in reverse transcriptase). We detect strong B * 18-dependent selection at the first anchor residue of NETPGIRYQY (site 138) [35, 37] . We do not detect selection at the other escape site. Further investigation of the literature reveals that the 'diminished response' induced by a variant at this site is actually recognised to much the same levels as the wild type epitope, and precedes outgrowth of the single variant at the first anchor residue in the single patient studied [38] . Moving on to protease in Supplementary Figure 15 , we detect a strong signal of selection within the B * 44 epitope EEMNLPGRW. This signal is particularly strong at the first anchor residue (site 35) where escape is known to occur [39, 40] .

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