Author: Metzger, Vincent T.; Lloyd-Smith, James O.; Weinberger, Leor S.
Title: Autonomous Targeting of Infectious Superspreaders Using Engineered Transmissible Therapies Document date: 2011_3_17
ID: 0gt21051_10
Snippet: For the vaccine, the model assumes optimistic immunization coverage (80% or 95% coverage) of both high-risk and low-risk populations and considers a vaccine that is 30% protective, slightly higher than reported in the recent 'Thai trial' [34] , or a hypothetical 50% protective vaccine; life-long efficacy is assumed for both vaccines (i.e. no HIV mutational escape) but not for the TIP. For the TIPs, we analyze interventions that generate a 0.5-Log.....
Document: For the vaccine, the model assumes optimistic immunization coverage (80% or 95% coverage) of both high-risk and low-risk populations and considers a vaccine that is 30% protective, slightly higher than reported in the recent 'Thai trial' [34] , or a hypothetical 50% protective vaccine; life-long efficacy is assumed for both vaccines (i.e. no HIV mutational escape) but not for the TIP. For the TIPs, we analyze interventions that generate a 0.5-Log to 1.5-Log viral-load reduction in vivo, as reported in a recent HIV gene-therapy trial [17] . The model predicts the effects of vaccination or TIP intervention on HIV/AIDS prevalence in a resource-poor sub-Saharan setting.
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