Author: Mehta, Reena; Scheffler, Margaret; Tapia, Lorena; Aideyan, Letisha; Patel, Kirtida D; Jewell, Alan M; Avadhanula, Vasanthi; Mei, Minghua; Garofalo, Roberto P; Piedra, Pedro A
Title: Lactate dehydrogenase and caspase activity in nasopharyngeal secretions are predictors of bronchiolitis severity Document date: 2014_8_12
ID: 0ow8oo82_37
Snippet: A limitation of our study is that it was performed at one site during one respiratory virus season and thus the findings may not be applicable to other regions with differences in demographics and viral epidemiology. In addition, subjects were recruited as part of two originally separate studies; those subjects recruited from the ICU were sampled within the first 24 hours of admission, but all other patients were enrolled and sampled at the time .....
Document: A limitation of our study is that it was performed at one site during one respiratory virus season and thus the findings may not be applicable to other regions with differences in demographics and viral epidemiology. In addition, subjects were recruited as part of two originally separate studies; those subjects recruited from the ICU were sampled within the first 24 hours of admission, but all other patients were enrolled and sampled at the time of presentation to the ER. This may have impacted on NW-LDH activity with higher concentrations detected later into the acute phase of the illness. This, in part, is supported by a significantly higher proportion of children admitted to the ACU on days 3-5 of illness compared with children who were discharged home from the emergency department.
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