Author: Mazalovska, Milena; Kouokam, J. Calvin
Title: Lectins as Promising Therapeutics for the Prevention and Treatment of HIV and Other Potential Coinfections Document date: 2018_5_8
ID: 0spmy8vn_47
Snippet: Toxoplasma gondii is an obligate intracellular parasite that causes the disease known as toxoplasmosis. According to the CDC, more than 30 million individuals in the USA are T. gondii carriers [126] . Even though Toxoplasma gondii infection is asymptomatic in most people, pregnant women and immunocompromised individuals are at high risk of severe disease [127, 128] . Two lectins isolated from plants, including ScLL and ArtinM, have been shown to .....
Document: Toxoplasma gondii is an obligate intracellular parasite that causes the disease known as toxoplasmosis. According to the CDC, more than 30 million individuals in the USA are T. gondii carriers [126] . Even though Toxoplasma gondii infection is asymptomatic in most people, pregnant women and immunocompromised individuals are at high risk of severe disease [127, 128] . Two lectins isolated from plants, including ScLL and ArtinM, have been shown to be beneficial in controlling T. gondii infection in mice [129] . The latter lectins induce the production of cytokines necessary to control T. gondii infection without any cytotoxicity. Additionally, they stimulate nitric oxide production by macrophages required for parasite killing. Eutirucallin, a plant lectin with broad antimicrobial properties, also showed antiparasitic activity in vitro against T. gondii [100] .
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