Author: Xu, Yingying; Yuen, Pak-Wai; Lam, Jenny Ka-Wing
Title: Intranasal DNA Vaccine for Protection against Respiratory Infectious Diseases: The Delivery Perspectives Document date: 2014_7_10
ID: 0bma2749_10
Snippet: Safety is always a primary concern with any vaccine products. DNA vaccines are generally considered to be safer than conventional vaccine approaches as they lack the risk of reversion to a disease causing state or secondary infection. Similar to other gene therapy, the major safety issue related to DNA vaccines is the risk of integration of the plasmid DNA into the host genome, causing insertional mutagenesis, which may lead to the inactivation o.....
Document: Safety is always a primary concern with any vaccine products. DNA vaccines are generally considered to be safer than conventional vaccine approaches as they lack the risk of reversion to a disease causing state or secondary infection. Similar to other gene therapy, the major safety issue related to DNA vaccines is the risk of integration of the plasmid DNA into the host genome, causing insertional mutagenesis, which may lead to the inactivation of tumour suppressor genes or activation of oncogenes, resulting in devastating adverse effects. According to preclinical and clinical studies, there is little evidence of genomic integration following DNA vaccines administration, and the risk of integration is found to be significantly lower than the spontaneous mutation rate [33] [34] [35] [36] .
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