Author: Lee, Yu-Ching; Tsai, Keng-Chang; Leu, Sy-Jye; Wang, Tuan-Jen; Liu, Chia-Yu; Yang, Yi-Yuan
Title: Isolation, Characterization, and Molecular Modeling of a Rheumatoid Factor from a Hepatitis C Virus Infected Patient with Sjögren's Syndrome Document date: 2013_12_30
ID: 0zsn4lu3_33
Snippet: IgG Fc Antigen. To investigate the interaction of RFL11 with IgG Fc, the six CDRs of RFL11, all of which make contact except CDR-L2 loop and the H2 and H3 loops of RFL11 that dominate the interaction with Fc, are shown in Figure 8 . From the interaction between CDR-L2 loop and IgG Fc, we found that Phe85 side chain and Tyr49 side chain on the H2 loop correspondingly act on Asp356 and Lys439 on the IgG Fc, respectively, and the interactions involv.....
Document: IgG Fc Antigen. To investigate the interaction of RFL11 with IgG Fc, the six CDRs of RFL11, all of which make contact except CDR-L2 loop and the H2 and H3 loops of RFL11 that dominate the interaction with Fc, are shown in Figure 8 . From the interaction between CDR-L2 loop and IgG Fc, we found that Phe85 side chain and Tyr49 side chain on the H2 loop correspondingly act on Asp356 and Lys439 on the IgG Fc, respectively, and the interactions involved are anion-pi interaction and cation-pi interaction, respectively. In addition to the two interactions, some H-bondings are also involved, as exemplified below. The side chain of Arg50 acts on the side chains of Gln438 and Tyr436 via two H-bondings; the side chains of Ser51 and Asn52 interact with the main chain of Gln438 and produce H-bondings; moreover, an H-bonding is also produced between the side chain of Asn52 and the side chain of Gln438.
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