Author: Li, Lv; Dai, Hong-Juan; Ye, Mao; Wang, Shu-Ling; Xiao, Xiao-Juan; Zheng, Jie; Chen, Hui-Yong; Luo, Yu-hao; Liu, Jing
Title: Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition Document date: 2012_11_23
ID: 13amcxh2_11
Snippet: To reveal the molecular mechanism of cell-cycle arrest in the G0/G1 phase, we investigated whether or not the effects induced by lycorine were associated with the level of G1-S transition-related proteins. After treating K562 cells with various concentrations of lycorine, we observed a dose-dependent decrease in cyclin D1 levels. The decrease in cyclin D1 expression observed in lycorine-treated cells was accompanied by a reduction in the amount o.....
Document: To reveal the molecular mechanism of cell-cycle arrest in the G0/G1 phase, we investigated whether or not the effects induced by lycorine were associated with the level of G1-S transition-related proteins. After treating K562 cells with various concentrations of lycorine, we observed a dose-dependent decrease in cyclin D1 levels. The decrease in cyclin D1 expression observed in lycorine-treated cells was accompanied by a reduction in the amount of CDK4 and CDK2 ( Figure 4A and 4B). By contrast, the expression patterns of cyclin E and CDK6 were not significantly altered after treatment with lycorine (data not shown).
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