Author: Li, Lv; Dai, Hong-Juan; Ye, Mao; Wang, Shu-Ling; Xiao, Xiao-Juan; Zheng, Jie; Chen, Hui-Yong; Luo, Yu-hao; Liu, Jing
Title: Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition Document date: 2012_11_23
ID: 13amcxh2_19
Snippet: In summary, our data show that lycorine can inhibit proliferation of the human CML cell line K562 through G0/G1 phase arrest, which is mediated by the regulation of G1-related protein. Meanwhile, the inhibition of HDAC enzymatic activity is involved in the effect of lycorine on K562 cells. Further in-depth in vivo studies are presently under investigation in our laboratory......
Document: In summary, our data show that lycorine can inhibit proliferation of the human CML cell line K562 through G0/G1 phase arrest, which is mediated by the regulation of G1-related protein. Meanwhile, the inhibition of HDAC enzymatic activity is involved in the effect of lycorine on K562 cells. Further in-depth in vivo studies are presently under investigation in our laboratory.
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