Author: Li, Lv; Dai, Hong-Juan; Ye, Mao; Wang, Shu-Ling; Xiao, Xiao-Juan; Zheng, Jie; Chen, Hui-Yong; Luo, Yu-hao; Liu, Jing
Title: Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition Document date: 2012_11_23
ID: 13amcxh2_6
Snippet: To determine the effect of lycorine on the growth of CML cells, K562 cells were treated with lycorine at various concentrations and examined by manual cell counting every 24 h for 72 h. Compared with the control group, the cells density of the group treated with 5.0 μM lycorine increased very slightly from 24 h to 72 h, which indicates that lycorine significantly inhibits the growth of K562 cells ( Figure 1A ). CCK-8 assays showed that the viabi.....
Document: To determine the effect of lycorine on the growth of CML cells, K562 cells were treated with lycorine at various concentrations and examined by manual cell counting every 24 h for 72 h. Compared with the control group, the cells density of the group treated with 5.0 μM lycorine increased very slightly from 24 h to 72 h, which indicates that lycorine significantly inhibits the growth of K562 cells ( Figure 1A ). CCK-8 assays showed that the viability of K562 cells exposed to various concentrations of lycorine (1.25, 2.5, and 5.0 μM) decreased from 82% to 54% after 24 h and from 80% to 42% after 48 h, which reveals that lycorine inhibits the proliferation of K562 cells in a dose-dependent manner ( Figure 1B ).
Search related documents:
Co phrase search for related documents- cell counting and dose dependent manner: 1, 2, 3, 4
- cell counting and lycorine effect: 1
- cell counting and manual cell counting: 1
- cell density and control group: 1, 2, 3, 4, 5, 6, 7
- cell density and dose dependent manner: 1, 2
- cell density and group cell density: 1, 2, 3, 4, 5
- CML cell and dose dependent manner: 1
- CML cell and lycorine effect: 1
- control group and dose dependent manner: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
- control group and group cell density: 1, 2, 3
- control group and lycorine effect: 1
- control group and slightly increase: 1, 2
- dose dependent manner and lycorine effect: 1
- μm lycorine and lycorine concentration: 1, 2
- μm lycorine and lycorine effect: 1, 2
- μm lycorine and lycorine treat: 1
- lycorine effect and manual cell counting: 1
Co phrase search for related documents, hyperlinks ordered by date