Author: Li, Lv; Dai, Hong-Juan; Ye, Mao; Wang, Shu-Ling; Xiao, Xiao-Juan; Zheng, Jie; Chen, Hui-Yong; Luo, Yu-hao; Liu, Jing
Title: Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition Document date: 2012_11_23
ID: 13amcxh2_4
Snippet: In this study, we further reveal that lycorine can inhibit proliferation of the human CML cell line K562. Analysis of HDAC activity shows that lycroine decreases HDAC enzymatic activities in K562 cells in a dosedependent manner. To determine the effect of HDAC inhibition, we evaluate the cell cycle distribution after lycorine treatment. We show that lycorine inhibits the proliferation of K562 cells through G0/G1 phase arrest, which is mediated by.....
Document: In this study, we further reveal that lycorine can inhibit proliferation of the human CML cell line K562. Analysis of HDAC activity shows that lycroine decreases HDAC enzymatic activities in K562 cells in a dosedependent manner. To determine the effect of HDAC inhibition, we evaluate the cell cycle distribution after lycorine treatment. We show that lycorine inhibits the proliferation of K562 cells through G0/G1 phase arrest, which is mediated by the regulation of G1-related proteins. After lycorine treatment, cyclin D1 and cyclindependent kinase 4 (CDK4) expressions are inhibited and retinoblastoma protein (pRB) phosphorylation is reduced. Lycorine treatment also significantly upregulates the expression of p53 and its target gene product, p21. These results suggest that inhibition of HDAC activity is responsible for at least part of the induction of G1 cell-cycle arrest of K562 cells by lycorine.
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