Selected article for: "cell cycle and HDAC activity inhibition"
Author: Li, Lv; Dai, Hong-Juan; Ye, Mao; Wang, Shu-Ling; Xiao, Xiao-Juan; Zheng, Jie; Chen, Hui-Yong; Luo, Yu-hao; Liu, Jing
Title: Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition
  • Document date: 2012_11_23
    • ID: 13amcxh2_9
    Snippet: Lycorine induces cell cycle arrest in the G0/G1 phase Inhibition of HDAC activity has been associated with cell-cycle arrest and growth inhibition. Thus, we determined whether or not lycorine can interfere with cell cycle progression by flow cytometry. After K562 cells were treated with 5 μM lycorine, the percentage of cells in the G0/G1 phase increased significantly from 35.9% to 41.9% while S-phase cells showed only a slight increased. The per.....
    Document: Lycorine induces cell cycle arrest in the G0/G1 phase Inhibition of HDAC activity has been associated with cell-cycle arrest and growth inhibition. Thus, we determined whether or not lycorine can interfere with cell cycle progression by flow cytometry. After K562 cells were treated with 5 μM lycorine, the percentage of cells in the G0/G1 phase increased significantly from 35.9% to 41.9% while S-phase cells showed only a slight increased. The percentage of G2/M-phase cells decreased from 12.3% in the untreated group to 4.44% in the treated group ( Figure 3 ). This finding indicates that cell cycle distribution was blocked significantly in the G0/G1 phase when K562 cells are treated with lycorine.

    Search related documents:
    Co phrase search for related documents
    • flow cytometry and G0 G1 phase inhibition: 1
    • flow cytometry and growth inhibition: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • flow cytometry and growth inhibition cell cycle arrest: 1
    • flow cytometry and HDAC activity: 1
    • flow cytometry and μM lycorine: 1
    • flow cytometry and significantly increase: 1, 2, 3, 4
    • flow cytometry and slight increase: 1, 2, 3
    • flow cytometry and treat group: 1
    • flow cytometry and untreated group: 1, 2
    • G0 G1 phase and growth inhibition: 1, 2, 3
    • G0 G1 phase and growth inhibition cell cycle arrest: 1
    • G0 G1 phase and HDAC activity: 1, 2, 3, 4
    • G0 G1 phase and slight increase: 1
    • growth inhibition and HDAC activity: 1, 2
    • growth inhibition cell cycle arrest and HDAC activity: 1
    • μM lycorine and lycorine treat: 1